5 Amino 1MQ

Molecular Overview

5-Amino-1MQ is a small-molecule compound studied for its inhibitory action on Nicotinamide N-Methyltransferase (NNMT), an enzyme involved in cellular energy regulation and fat accumulation pathways. Elevated NNMT activity has been associated with metabolic inefficiency and increased fat storage in research models.

Key research associations include:

· NNMT inhibition and metabolic regulation

· Support for fat metabolism and energy expenditure pathways

· Improved cellular NAD⁺ availability in models

· Influence on adipocyte (fat cell) function

· Regulation of metabolic efficiency and fuel utilization

These properties position 5-Amino-1MQ as a high-interest compound in metabolic and body composition research.

Mechanisms of Action

1. NNMT Inhibition 5-Amino-1MQ limits NNMT activity, which is associated with improved metabolic efficiency and reduced fat storage signaling in research models.

2. Metabolic Pathway Optimization By influencing NAD⁺-related pathways, 5-Amino-1MQ is studied for its role in enhancing cellular energy utilization.

3. Adipose Tissue Regulation Research suggests 5-Amino-1MQ may affect fat cell behavior, supporting studies focused on adipose tissue reduction and metabolic balance.

Physiological & Performance-Related Research Benefits

· Support for metabolic efficiency and energy balance

· Reduction of fat accumulation markers in research models

· Enhancement of cellular fuel utilization

· Support of NAD⁺-related metabolic pathways

· Promotion of lean mass preservation in studies

· Improvement of metabolic resilience under caloric stress

Therapeutic Research Applications

5-Amino-1MQ is commonly explored in studies involving:

· Metabolic health and obesity research

· Fat loss and body recomposition models

· NNMT enzyme pathway studies

· Energy expenditure and fuel utilization research

· Insulin sensitivity and metabolic stress models

· Aging and metabolic decline research

· Adipose tissue biology studies

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Molecular Formula

5-Amino-1MQ

· Compound Name: 5-Amino-1-Methylquinolinium (5-Amino-1MQ)

· Molecular Formula: C₁₀H₁₁N₂⁺

· Molecular Weight: Approximately 173.2 g/mol (free base)

1. What is 5-Amino-1MQ and why does it matter?

5-Amino-1MQ is a research compound studied for its ability to inhibit NNMT, an enzyme linked to metabolic inefficiency and fat storage. By targeting this pathway, researchers investigate how 5-Amino-1MQ may support improved energy balance and metabolic outcomes in laboratory models.

2. What are the research benefits of 5-Amino-1MQ?

Research suggests 5-Amino-1MQ may:

· Support fat metabolism and energy expenditure

· Improve metabolic efficiency at the cellular level

· Influence NAD⁺ availability and energy pathways

· Reduce fat-storage signaling in adipose tissue models

· Support lean mass preservation in research settings

· Demonstrate favorable stability for laboratory use

3. What is 5-Amino-1MQ used for in research?

5-Amino-1MQ is primarily used in laboratory and preclinical research focused on:

· Weight and fat-loss mechanisms

· Metabolic optimization

· NNMT pathway inhibition

· Energy balance and fuel partitioning

· Obesity and metabolic syndrome models

Due to its targeted metabolic mechanism, 5-Amino-1MQ continues to be a high-demand compound in advanced metabolic research.

https://pubmed.ncbi.nlm.nih.gov/9413147/

https://pubmed.ncbi.nlm.nih.gov/10427129/

https://pubmed.ncbi.nlm.nih.gov/9114437/