BPC-157

BPC-157 (Body Protection Compound-157): Molecular Mechanisms and Regenerative Functions

Molecular Overview

BPC-157 is a 15-amino acid synthetic peptide derived from a naturally occurring protective protein in gastric juice.

It functions as a cytoprotective and tissue-regenerative agent, promoting healing in muscle, tendon, ligament, gastrointestinal, and neural tissues.

BPC-157 exhibits angiogenic, anti-inflammatory, and neuroprotective properties, making it a highly studied molecule in tissue repair, recovery, and gastrointestinal integrity research.

Mechanism of Action

1. Tissue Repair and Regeneration

• BPC-157 enhances fibroblast proliferation, collagen deposition, and angiogenesis, accelerating wound healing in soft tissues, ligaments, and tendons.
• Upregulates VEGF (vascular endothelial growth factor) and FGF (fibroblast growth factor) pathways to improve microvascular formation and nutrient delivery to injured tissues.
   

2. Anti-Inflammatory Effects

• Modulates pro-inflammatory cytokines (e.g., TNF-α, IL-6) while promoting anti-inflammatory mediators such as IL-10.
• Reduces systemic and localized inflammation, supporting pain relief and tissue protection in both musculoskeletal and gastrointestinal systems.
   

3. Gastrointestinal Protection and Healing

• Promotes epithelial cell proliferation and mucosal repair in the gut lining, protecting against ulcers, leaky gut, and inflammatory GI conditions.
• Enhances nitric oxide (NO) signaling to improve blood flow and tissue resilience in gastrointestinal tissues.
   

4. Neuroprotection and Stress Resilience

• Supports neuronal survival, reduces neuroinflammation, and may protect against oxidative stress-induced neuronal damage.
• Enhances the body’s capacity to adapt to physical strain and recover from stress-induced tissue damage.

Physiological and Clinical Benefits

• Accelerated Healing: Promotes rapid recovery of muscles, tendons, ligaments, and connective tissue.
• Inflammation Reduction: Soothes systemic and localized inflammatory responses.
• Gastrointestinal Support: Repairs gut lining and promotes digestive balance.
• Enhanced Resilience: Improves recovery from physical and metabolic stress.
• Neuroprotective Effects: Supports brain function and mitigates neuroinflammation.

Therapeutic and Research Applications

BPC-157 is commonly explored and applied for:

• Soft tissue repair (muscle, tendon, ligament injuries)
• Post-surgical healing and rehabilitation
• Chronic inflammation and joint pain management
• Gastrointestinal disorders (ulcers, leaky gut, IBS)
• Neuroprotection and stress adaptation studies
• Athletic performance recovery and injury prevention

BPC-157 represents a multi-functional regenerative peptide, combining angiogenic, cytoprotective, and anti-inflammatory activities to accelerate tissue repair, optimize recovery, and maintain systemic resilience.

Legal Policy: 

This product is strictly for research purposes only and is intended solely for in vitro testing and laboratory experimentation. The information provided on this website is for educational use and does not permit the introduction of this product into humans or animals. Handling of this product is restricted to licensed and qualified professionals. It is not classified as a drug, food, or cosmetic, and should not be misrepresented or used as such.

All products sold on this site are for research and development use only. They are not intended for human or animal use.

The statements on this website have not been evaluated by the US Food and Drug Administration (FDA). Our products and content are not intended to diagnose, treat, cure, or prevent any disease.

Tides Peptides is a chemical supplier, not a compounding pharmacy or a chemical compounding facility as defined under section 503A of the Federal Food, Drug, and Cosmetic Act.

CAS NO.: 137525-51-0

Molecular Formula: C62H98N16O22

Molecular Weight: 1419.56g/mol

Amino acid sequence: Gly-Glu-Pro-Pro-Pro-Gly-Lys-Pro-Ala-Asp-Asp-Ala-Gly-Leu-Val

View Certificate of Analysis

1. What is BPC-157, and why does it matter?

BPC-157 (Body Protection Compound-157) is a synthetic peptide derived from a protective protein found in the stomach. It’s known for its powerful healing and regenerative properties, especially in soft tissue, joints, and the digestive system. It helps accelerate recovery and supports overall body repair.

2. What are the benefits of BPC-157?

Users often take BPC-157 to support:

• Faster healing of injuries (muscle, tendon, ligament)

• Reduced inflammation and joint pain

• Improved gut health and GI repair

• Enhanced recovery from workouts or surgery

• Protection against oxidative stress and cell damage

It’s widely used by athletes, active individuals, and those recovering from injuries or chronic inflammation.

3. What is BPC-157 used for?

BPC-157 is commonly used to:

• Speed up injury recovery

• Reduce chronic pain or inflammation

• Heal gut issues like leaky gut or ulcers

• Support post-surgical healing

• Protect and repair tissues under stress

It’s a go-to peptide for anyone looking to recover faster and support long-term tissue health.

Safety of Intravenous Infusion of BPC157 in Humans: A Pilot Study.
Lee E, Burgess K.
Altern Ther Health Med. 2025 Mar 26:AT11513. Online ahead of print.
PMID: 40131143

Multifunctionality and Possible Medical Application of the BPC 157 Peptide-Literature and Patent Review.
Józwiak M, Bauer M, Kamysz W, Kleczkowska P.
Pharmaceuticals (Basel). 2025 Jan 30;18(2):185. doi: 10.3390/ph18020185.
PMID: 40005999

Protective Effects of BPC 157 on Liver, Kidney, and Lung Distant Organ Damage in Rats with Experimental Lower-Extremity Ischemia-Reperfusion Injury.
Demirtaş H, Özer A, Yıldırım AK, Dursun AD, Sezen ŞC, Arslan M.
Medicina (Kaunas). 2025 Feb 8;61(2):291. doi: 10.3390/medicina61020291.
PMID: 40005408

Editorial Commentary: Testosterone, Growth Hormone, and Vitamin D Supplementation Is Not Routinely Indicated for Orthopaedic Surgery Patients.
Dekker TJ.
Arthroscopy. 2025 Feb 3:S0749-8063(25)00051-9. doi: 10.1016/j.arthro.2025.01.033. Online ahead of print.
PMID: 39909207

Withdrawn: Stable Gastric Pentadecapeptide BPC 157 as a Therapy of Severe Electrolyte Disturbances in Rats.
Grubisic MM, Strbe S, Barisic I, Balenovic D, Stambolija V, Lozic M, Ostojic SB, Oreskovic I, Zizek H, Brcic K, Coric L, Staresinic M, Blagaic V, Oreskovic LB, Halle ZB, Matek D, Soldo D, Grizelj B, Blagaic AB, Skrtic A, Sikiric P, Seiwerth S.
Curr Neuropharmacol. 2025 Jan 24. doi: 10.2174/011570159X349612241205065330. Online ahead of print.
PMID: 39865815

Stable Gastric Pentadecapeptide BPC 157 as Therapy After Surgical Detachment of the Quadriceps Muscle from Its Attachments for Muscle-to-Bone Reattachment in Rats.
Matek D, Matek I, Staresinic E, Japjec M, Bojanic I, Boban Blagaic A, Beketic Oreskovic L, Oreskovic I, Ziger T, Novinscak T, Krezic I, Strbe S, Drinkovic M, Brkic F, Popic J, Skrtic A, Seiwerth S, Staresinic M, Sikiric P, Brizic I.
Pharmaceutics. 2025 Jan 16;17(1):119. doi: 10.3390/pharmaceutics17010119.
PMID: 39861766

Compounded glucagon-like peptide-1 receptor agonists for weight loss: the direct-to-consumer market in Colorado.
DiStefano MJ, Dardouri M, Moore GD, Saseen JJ, Nair KV.
J Pharm Policy Pract. 2024 Dec 24;18(1):2441220. doi: 10.1080/20523211.2024.2441220. eCollection 2025.
PMID: 39776466

Compounded glucagon-like peptide-1 receptor agonists for weight loss: the direct-to-consumer market in Colorado.
DiStefano MJ, Dardouri M, Moore GD, Saseen JJ, Nair KV.
J Pharm Policy Pract. 2024 Dec 24;18(1):2441220. doi: 10.1080/20523211.2024.2441220. eCollection 2025.
PMID: 39776466

Effect of BPC-157 on Symptoms in Patients with Interstitial Cystitis: A Pilot Study.
Lee E, Walker C, Ayadi B.
Altern Ther Health Med. 2024 Oct;30(10):12-17.
PMID: 39325560

Injectable Therapeutic Peptides-An Adjunct to Regenerative Medicine and Sports Performance?
DeFoor MT, Dekker TJ.
Arthroscopy. 2025 Feb;41(2):150-152. doi: 10.1016/j.arthro.2024.09.005. Epub 2024 Sep 10.
PMID: 39265666

Stable Gastric Pentadecapeptide BPC 157 and Intestinal Anastomoses Therapy in Rats-A Review.
Bajramagic S, Sever M, Rasic F, Staresinic M, Skrtic A, Beketic Oreskovic L, Oreskovic I, Strbe S, Loga Zec S, Hrabar J, Coric L, Prenc M, Blagaic V, Brcic K, Boban Blagaic A, Seiwerth S, Sikiric P.
Pharmaceuticals (Basel). 2024 Aug 17;17(8):1081. doi: 10.3390/ph17081081.
PMID: 39204186