KLOW Blend 80mg

Molecular Overview

KLOW is a synthetic research peptide fragment designed to mimic or modulate specific protein–protein signaling pathways involved in cellular adaptation, metabolic regulation, and tissue resilience. Structurally, it is composed of a short chain of amino acids arranged to maintain stability, receptor affinity, and predictable degradation in experimental models. In biochemical assays, KLOW demonstrates:

• High receptor-binding selectivity for target cell-surface or intracellular signaling proteins
• Favorable solubility for in vitro and in vivo laboratory applications
• Moderate enzymatic stability, enabling measurable pharmacodynamics while limiting long-term accumulation

Mechanism of Action

Although the full pathway interaction profile is still under investigation, current research models suggest that KLOW:

• Interacts with regulatory signaling complexes, potentially influencing downstream cascades such as AMPK, ERK, or other kinase pathways involved in metabolic and cellular stress responses.
• Modulates transcriptional activity, possibly adjusting gene expression profiles related to energy balance, mitochondrial activity, or repair processes.
• Alters intercellular communication, which may affect growth factors, cytokine release, or neuromodulator signals depending on the tissue model.

These proposed mechanisms point to KLOW functioning as a signal-modifying peptide, altering cellular responses rather than acting as a direct enzyme inhibitor or substrate.

Metabolic and Physiological Outcomes

Across laboratory studies, KLOW has been associated with several measurable outcomes:

• Metabolic Regulation:
  Research models indicate shifts in energy utilization, mitochondrial efficiency, or glucose/fatty acid metabolic pathways following peptide exposure.
• Cellular Stress Modulation:
  KLOW may influence oxidative stress markers, inflammatory mediators, or heat-shock pathway activation.
• Tissue-Specific Adaptations:
  Depending on the experimental system, investigators have observed changes in cellular proliferation, recovery markers, or baseline functional performance metrics.

Clinical and Research Significance

The scientific interest in KLOW stems from its potential to:

• Serve as a tool for dissecting metabolic regulation pathways, offering insight into energy homeostasis, insulin signaling, and mitochondrial biology.
• Model peptide–receptor interactions for drug discovery, aiding the development of new modulators for metabolic or degenerative conditions.
• Support studies on tissue stress adaptation, offering a controlled means to influence or observe cellular resilience mechanisms.

Legal Policy:

This product is strictly for research purposes only and is intended solely for in vitro testing and laboratory experimentation. The information provided on this website is for educational use and does not permit the introduction of this product into humans or animals. Handling of this product is restricted to licensed and qualified professionals. It is not classified as a drug, food, or cosmetic, and should not be misrepresented or used as such.

All products sold on this site are for research and development use only. They are not intended for human or animal use.
 

The statements on this website have not been evaluated by the US Food and Drug Administration (FDA). Our products and content are not intended to diagnose, treat, cure, or prevent any disease.

Tides Peptides is a chemical supplier, not a compounding pharmacy or a chemical compounding facility as defined under section 503A of the Federal Food, Drug, and Cosmetic Act.

Molecular Formula

BPC‑157

• Amino Acid Sequence: Gly‑Glu‑Pro‑Pro‑Pro‑Gly‑Lys‑Pro‑Ala‑Asp‑Asp‑Ala‑Gly‑Leu‑Val
• Formula: C₆₂H₉₈N₁₆O₂₂
• Molecular Weight: 1,419.5 g/mol

TB‑500 (Thymosin β4 fragment 17–23)

• Amino Acid Sequence: N‑Ac‑Ser‑Asp‑Lys‑Pro‑His‑Gln‑Ala‑Gly
• Formula (combined): C₈₂H₁₃₃N₂₁O₂₈S
• Approx. Molecular Weight: ~1,894 g/mol

GHK-Cu

• Sequence: Gly-His-Lys.Cu.XHAc
• Formula: C₁₄H₂₃CuN₆O₄
• Molecular Weight: ~401.97 g/mol

KPV

• Amino Acid Sequence: Lys-Pro-Val
• Molecular Formula: C₁₈H₃₄N₄O₅
• Molecular Weight ~386.49 g/mol

1. What is the KLOW Blend, and why does it matter?

The “KLOW Blend” is a combined peptide formulation typically containing four research peptides: BPC-157, TB-500, GHK-Cu, and KPV in a 10/10/50/10 mg ratio (total 80 mg).

It has been studied for tissue repair, inflammation modulation, and cellular health into a single mixture. The idea is that the peptides may have complementary or synergistic biological roles in experimental or wellness contexts.

2. What are the proposed benefits of the KLOW Blend? (General informational overview)

BPC-157

• Cellular repair processes
• Gastrointestinal and tendon healing pathways

TB-500 (Thymosin Beta-4 fragment)

• Tissue regeneration mechanisms
• Angiogenesis (formation of new blood vessels)
• Recovery from soft-tissue injury

GHK-Cu

• Skin repair and collagen-related pathways
• Anti-oxidant and anti-inflammatory signaling
• Copper-dependent cellular functions

KPV (Lys-Pro-Val)

• Anti-inflammatory signaling pathways
• Support of epithelial or skin barrier function

3. What is the KLOW Blend used for?

Research shows the KLOW Blend groups peptides that are individually studied for tissue repair, inflammation modulation, and cellular health into a single mixture. The idea is that the peptides may have complementary or synergistic biological roles in experimental or wellness contexts.

Its importance is mainly in research or regenerative-wellness conversation, not in established medicine. General recovery support (athletic, soft-tissue, overuse strain)

• Inflammation-related research models
• Skin and cellular-health research
• Post-exercise or post-stress recovery protocols
• Anti-aging or cosmetic wellness interest (mainly due to GHK-Cu)

Pentadecapeptide BPC 157 Enhances the Growth Hormone Receptor Expression in Tendon Fibroblasts

This study explores the effects of BPC-157 on tendon fibroblasts, highlighting its potential in musculoskeletal tissue repair.

Gastric Pentadecapeptide Body Protection Compound BPC 157 and Its Role in Accelerating Musculoskeletal Soft Tissue Healing

This article reviews the role of BPC-157 in accelerating the healing of musculoskeletal soft tissues.

Stable Gastric Pentadecapeptide BPC 157 Can Improve the Healing Course of Spinal Cord Injury and Lead to Functional Recovery in Rats

This research examines the potential of BPC-157 in promoting recovery from spinal cord injuries. ​

Thymosin Beta-4: A Promising Peptide for Tissue Repair and Regeneration

This review discusses the regenerative effects of TB-500, focusing on its role in tissue repair and inflammation modulation.Subscribe Now

Regenerative and Protective Actions of the GHK-Cu Peptide in the Light of the New Gene Data.
Pickart L, Margolina A.Int J Mol Sci. 2018 Jul 7;19(7):1987. doi: 10.3390/ijms19071987.PMID: 29986520 Free PMC article. Review.

The potential of GHK as an anti-aging peptide.
Dou Y, Lee A, Zhu L, Morton J, Ladiges W.Aging Pathobiol Ther. 2020 Mar 27;2(1):58-61. doi: 10.31491/apt.2020.03.014.PMID: 35083444 Free PMC article.

Ternary Cu(II) Complex with GHK Peptide and Cis-Urocanic Acid as a Potential Physiologically Functional Copper Chelate.
Bossak-Ahmad K, Wiśniewska MD, Bal W, Drew SC, Frączyk T.Int J Mol Sci. 2020 Aug 27;21(17):6190. doi: 10.3390/ijms21176190.PMID: 32867146 Free PMC article.

The tri-peptide GHK-Cu complex ameliorates lipopolysaccharide-induced acute lung injury in mice.
Park JR, Lee H, Kim SI, Yang SR.Oncotarget. 2016 Sep 6;7(36):58405-58417. doi: 10.18632/oncotarget.11168.PMID: 27517151 Free PMC article.

GHK Peptide as a Natural Modulator of Multiple Cellular Pathways in Skin Regeneration.
Pickart L, Vasquez-Soltero JM, Margolina A.Biomed Res Int. 2015;2015:648108. doi: 10.1155/2015/648108. Epub 2015 Jul 7.PMID: 26236730 Free PMC article. Review.

Inhibition of cellular and systemic inflammation cues in human bronchial epithelial cells by melanocortin-related peptides: mechanism of KPV action and a role for MC3R agonists.

• Land SC.
• Int J Physiol Pathophysiol Pharmacol. 2012 Jun 23;4(2):59-73.
• PMCID: PMC3403564

PepT1-mediated tripeptide KPV uptake reduces intestinal inflammation.

• Dalmasso G, Charrier-Hisamuddin L, Nguyen HT, Yan Y, Sitaraman S, Merlin D.
• Gastroenterology. Author manuscript. 2007 Oct 17;134(1):166-78. doi: 10.1053/j.gastro.2007.10.026.
• PMCID: PMC2431115

A nanoparticle platform for combined mucosal healing and immunomodulation in inflammatory bowel disease treatment.

• Marotti V, Xu Y, Bohns Michalowski C, Zhang W, Domingues I, Ameraoui H, Moreels TG, Baatsen P, Van Hul M, Muccioli GG, Cani PD, Alhouayek M, Malfanti A, Beloqui A.
• Bioact Mater. 2023 Oct 11;32:206-221. doi: 10.1016/j.bioactmat.2023.09.014.
• PMCID: PMC10582360

alpha-MSH related peptides: a new class of anti-inflammatory and immunomodulating drugs.

• Luger TA, Brzoska T.
• Ann Rheum Dis. 2007 Nov;66 Suppl 3(Suppl 3):iii52-5. doi: 10.1136/ard.2007.079780.
• PMCID: PMC2095288