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MOTS-C
$90.00
MOTS-C is a peptide derived from mitochondria that plays a critical role in regulating metabolism and energy balance. It activates key pathways — such as AMPK — that boost glucose utilization, improve insulin sensitivity, and promote fat oxidation, particularly during metabolic stress. Research suggests that MOTS-C can mimic some of the cellular effects of exercise, helping to enhance energy output, support fat loss, and preserve lean muscle mass. This makes it especially promising for individuals dealing with metabolic resistance or age-related weight gain.
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Research
MOTS-C (Mitochondrial-Derived Peptide): Molecular Mechanisms and Metabolic Modulation
Molecular Overview
MOTS-C is a 16-amino acid peptide encoded by the mitochondrial genome (MT-RNR1). It belongs to the family of mitochondrial-derived peptides (MDPs), which act as signaling molecules to coordinate cellular energy homeostasis, stress responses, and metabolic adaptation.
MOTS-C is highly conserved across mammals and functions as a mitochondrial-nuclear retrograde signal, modulating nuclear gene expression to optimize energy metabolism under metabolic and oxidative stress.
Mechanism of Action
- AMPK Activation and Energy Homeostasis
MOTS-C directly activates AMP-activated protein kinase (AMPK), a master regulator of cellular energy balance.
– Promotes glucose uptake and glycolysis in skeletal muscle and adipose tissue.
– Enhances mitochondrial biogenesis and oxidative phosphorylation efficiency.
– Improves insulin sensitivity through downstream modulation of GLUT4 translocation and AKT signaling.
- Lipid Metabolism and Fat Oxidation
By upregulating fatty acid oxidation pathways and suppressing lipogenesis, MOTS-C shifts substrate utilization toward fatty acids over carbohydrate storage, facilitating adipose tissue reduction and enhanced metabolic flexibility.
- Exercise Performance and Endurance
MOTS-C supports skeletal muscle energy dynamics by optimizing mitochondrial ATP production and reducing reactive oxygen species (ROS) accumulation.
This enhances exercise tolerance, stamina, and endurance capacity, particularly during prolonged aerobic activity.
- Anti-Aging and Longevity Effects
Through AMPK activation and downstream modulation of FOXO, PGC-1α, and SIRT1 pathways, MOTS-C promotes cellular stress resistance, mitochondrial quality control, and metabolic adaptation, contributing to markers of healthy aging and longevity.
- Glucose Regulation
MOTS-C improves systemic glucose homeostasis by enhancing insulin signaling and increasing peripheral glucose uptake, reducing hyperglycemia and mitigating metabolic stress in insulin-resistant states.
Physiological and Clinical Effects
- Metabolic Boost: Enhances basal metabolic rate, glucose utilization, and insulin sensitivity.
- Fat Burning: Promotes lipolysis and fatty acid oxidation, reducing adipose tissue accumulation.
- Endurance Gains: Increases ATP efficiency, exercise stamina, and aerobic capacity.
- Longevity Support: Activates AMPK and mitochondrial maintenance pathways to support cellular resilience and healthy aging.
- Glucose Regulation: Optimizes insulin action and postprandial glycemia.
Therapeutic and Research Applications
MOTS-C is investigated for its potential in:
- Metabolic health optimization (insulin resistance, obesity, type 2 diabetes)
- Weight management and fat loss
- Exercise physiology and performance enhancement
- Anti-aging and longevity interventions
- Mitochondrial dysfunction and age-related metabolic disorders
As a mitochondrial-derived signaling peptide, MOTS-C exemplifies a mitohormetic regulator capable of integrating cellular energy metabolism, stress adaptation, and systemic metabolic homeostasis.
Legal Policy:
This product is strictly for research purposes only and is intended solely for in vitro testing and laboratory experimentation. The information provided on this website is for educational use and does not permit the introduction of this product into humans or animals. Handling of this product is restricted to licensed and qualified professionals. It is not classified as a drug, food, or cosmetic, and should not be misrepresented or used as such.
Disclaimer
All products sold on this site are for research and development use only. They are not intended for human or animal use.
The statements on this website have not been evaluated by the US Food and Drug Administration (FDA). Our products and content are not intended to diagnose, treat, cure, or prevent any disease.
Tides Peptides is a chemical supplier, not a compounding pharmacy or a chemical compounding facility as defined under section 503A of the Federal Food, Drug, and Cosmetic Act.
Ingredients
Molecular Formula
- Sequence: H-Met-Arg-Trp-GIn-Glu-Met-Gly-Tyr-lle-Phe-Tyr- Pro-Arg-Lys-Leu-Arg-OH
- Formula: C₁₀₁H₁₅₂N₂₈O₂₂S₂
- Molecular Weight: ~2174.64 g/mol
FAQ
1. What is MOTS-C, and why does it matter?
MOTS-C is a mitochondrial-derived peptide that plays a key role in regulating metabolism and cellular energy. It matters because it helps the body adapt to metabolic stress and supports healthy aging.
2. What are the benefits of MOTS-C?
People use MOTS-C for:
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Improved energy and endurance
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Enhanced fat metabolism
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Support for healthy aging and longevity
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Better glucose regulation and insulin sensitivity
3. What is MOTS-C used for?
MOTS-C is often used to boost physical performance, support metabolic health, aid in weight management, and promote healthy aging.
White Papers
MOTS-c Functionally Prevents Metabolic Disorders.
Gao Y, Wei X, Wei P, Lu H, Zhong L, Tan J, Liu H, Liu Z.Metabolites. 2023 Jan 13;13(1):125. doi: 10.3390/metabo13010125.PMID: 36677050 Free PMC article. Review.
MOTS-c: A promising mitochondrial-derived peptide for therapeutic exploitation.
Zheng Y, Wei Z, Wang T.Front Endocrinol (Lausanne). 2023 Jan 25;14:1120533. doi: 10.3389/fendo.2023.1120533. eCollection 2023.PMID: 36761202 Free PMC article. Review.
MOTS-c reduces myostatin and muscle atrophy signaling.
Kumagai H, Coelho AR, Wan J, Mehta HH, Yen K, Huang A, Zempo H, Fuku N, Maeda S, Oliveira PJ, Cohen P, Kim SJ.Am J Physiol Endocrinol Metab. 2021 Apr 1;320(4):E680-E690. doi: 10.1152/ajpendo.00275.2020. Epub 2021 Feb 8.PMID: 33554779 Free PMC article.
Mitochondrial-Encoded Peptide MOTS-c, Diabetes, and Aging-Related Diseases.
Kong BS, Lee C, Cho YM.Diabetes Metab J. 2023 May;47(3):315-324. doi: 10.4093/dmj.2022.0333. Epub 2023 Feb 24.PMID: 36824008 Free PMC article. Review.
Role of MOTS-c in the regulation of bone metabolism.
Yi X, Hu G, Yang Y, Li J, Jin J, Chang B.Front Physiol. 2023 May 2;14:1149120. doi: 10.3389/fphys.2023.1149120. eCollection 2023.PMID: 37200834 Free PMC article. Review.
MOTS-c: A potential anti-pulmonary fibrosis factor derived by mitochondria.
Zhang Z, Chen D, Du K, Huang Y, Li X, Li Q, Lv X.Mitochondrion. 2023 Jul;71:76-82. doi: 10.1016/j.mito.2023.06.002. Epub 2023 Jun 10.PMID: 37307934 Review.
The mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis and reduces obesity and insulin resistance.
Lee C, Zeng J, Drew BG, Sallam T, Martin-Montalvo A, Wan J, Kim SJ, Mehta H, Hevener AL, de Cabo R, Cohen P.Cell Metab. 2015 Mar 3;21(3):443-54. doi: 10.1016/j.cmet.2015.02.009.PMID: 25738459 Free PMC article.
The mitochondrial-derived peptide MOTS-c relieves hyperglycemia and insulin resistance in gestational diabetes mellitus.
Yin Y, Pan Y, He J, Zhong H, Wu Y, Ji C, Liu L, Cui X.Pharmacol Res. 2022 Jan;175:105987. doi: 10.1016/j.phrs.2021.105987. Epub 2021 Nov 17.PMID: 34798268
MOTS-c, the Most Recent Mitochondrial Derived Peptide in Human Aging and Age-Related Diseases.
Mohtashami Z, Singh MK, Salimiaghdam N, Ozgul M, Kenney MC.Int J Mol Sci. 2022 Oct 9;23(19):11991. doi: 10.3390/ijms231911991.PMID: 36233287 Free PMC article. Review.
