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Thymosin Alpha 1

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$149.00

Thymosin Alpha 1, often called the “immune-boosting peptide,” is a naturally occurring molecule that plays a crucial role in regulating and enhancing immune function. Originally derived from the thymus gland, it helps the body defend against infection, inflammation, and chronic disease. Thymosin Alpha 1 is widely recognized for its ability to modulate immune responses, support healing, and promote resilience during periods of stress or illness.

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Research

Thymosin Alpha-1 (Tα1): Molecular Mechanisms and Immunomodulatory Functions

 

Molecular Overview

 

Thymosin Alpha-1 (Tα1) is a naturally occurring 28-amino acid immunomodulatory peptide derived from the thymus gland. It plays a critical role in orchestrating innate and adaptive immune responses, enhancing the body’s ability to detect and respond to pathogens, while maintaining immune homeostasis.

 

Tα1 functions as a biological signaling molecule, modulating T-cell differentiation, dendritic cell activation, and cytokine production, making it a cornerstone peptide in immune optimization and host defense.

 

Mechanism of Action

 

  • Innate Immune Enhancement
    Tα1 primes dendritic cells and natural killer (NK) cells, increasing antigen presentation and cytotoxic activity.

    It enhances pattern recognition receptor (PRR) signaling, such as TLR2 and TLR9, to improve the initial immune detection of viruses, bacteria, and fungi.
     
  • Adaptive Immune Regulation
    Tα1 promotes T-cell maturation and differentiation, particularly CD4⁺ helper T cells and CD8⁺ cytotoxic T cells, while regulating regulatory T-cell (Treg) populations.

    This balancing effect prevents immune overactivation while maintaining effective pathogen clearance, reducing the risk of autoimmune flare-ups.
     
  • Inflammation Modulation
    Tα1 modulates pro- and anti-inflammatory cytokine networks, reducing excessive inflammatory responses through NF-κB inhibition and IL-10 upregulation, promoting tissue protection during infection or immune stress.
     
  • Tissue Recovery and Resilience
    By supporting immune surveillance and optimizing cytokine signaling, Tα1 enhances healing processes following infection, injury, or surgical intervention. It improves cellular resilience against metabolic and oxidative stress.

 

Physiological and Clinical Effects

 

  • Enhanced Immune Function: Strengthens host defenses against bacterial, viral, and fungal pathogens.
  • Immune Regulation: Balances immune activity to prevent over- or under-reactivity.
  • Accelerated Recovery: Supports post-infection, post-surgical, and post-stress tissue repair.
  • Anti-Inflammatory Support: Reduces systemic and localized inflammatory signaling.
  • Chronic Condition Support: Provides adjunctive immunomodulation in autoimmune or immune-deficient states.

 

Therapeutic and Research Applications

 

Thymosin Alpha-1 is widely studied and applied in:

  • Immune support during viral exposure or illness
  • Adjunct therapy for chronic inflammatory or autoimmune disorders
  • Post-surgical or post-infection recovery
  • Immune optimization in immunocompromised patients or cancer therapy
  • Stress resilience and prophylactic immune support in high-risk environments

 

Tα1 represents a prototypical immunoregulatory peptide, combining host defense enhancement, immune homeostasis, and recovery support within a single molecular framework, making it a versatile agent in both clinical and research settings.

 

Legal Policy: 

This product is strictly for research purposes only and is intended solely for in vitro testing and laboratory experimentation. The information provided on this website is for educational use and does not permit the introduction of this product into humans or animals. Handling of this product is restricted to licensed and qualified professionals. It is not classified as a drug, food, or cosmetic, and should not be misrepresented or used as such.

Disclaimer

All products sold on this site are for research and development use only. They are not intended for human or animal use.

 

The statements on this website have not been evaluated by the US Food and Drug Administration (FDA). Our products and content are not intended to diagnose, treat, cure, or prevent any disease.

 

Tides Peptides is a chemical supplier, not a compounding pharmacy or a chemical compounding facility as defined under section 503A of the Federal Food, Drug, and Cosmetic Act.

Ingredients

Molecular Formula

  • Sequence: Ac‑Ser‑Asp‑Ala‑Glu‑Ile‑Thr‑Thr‑Gly‑Ser‑Val‑Tyr‑Glu‑Thr‑Gly‑
    Ser‑Glu‑Cys‑Lys‑Ala‑Lys‑Asp‑Asp‑Ala‑Val‑Asp‑Ala‑Glu‑Val‑
    Ile‑Val‑His‑Pro‑Glu‑Gln
  • Formula: C₁₃₆H₂₂₂N₃₈O₅₆S
  • Molecular Weight: ~3,108 g/mol

 

View Certificate of Analysis

 

FAQ

1. What is Thymosin Alpha-1, and why does it matter?

Thymosin Alpha-1 (Tα1)  plays a vital role in regulating the immune system, enhancing the body’s ability to fight off infections, viruses, and chronic inflammation. It’s especially valuable for immune optimization, recovery, and overall resilience.

 

2. What are the benefits of Thymosin Alpha-1?

Thymosin Alpha-1 is widely used for its immune-boosting and protective properties. Reported benefits include:

  • Strengthened immune system response

  • Increased resistance to infections and viruses

  • Reduced inflammation and autoimmune flare-ups

  • Faster recovery from illness or physical stress

  • Potential support in chronic conditions and immune dysfunction

It’s a popular option for those looking to stay healthy, especially during high-stress or high-risk periods.

 

3. What is Thymosin Alpha-1 used for?

Common uses of Thymosin Alpha-1 include:

  • Immune support during illness or viral exposure

  • Managing chronic inflammation or autoimmune conditions

  • Enhancing recovery after infection, surgery, or physical stress

  • Supporting cancer therapy or immune-challenged individuals (under medical supervision)

  • Boosting resilience during periods of travel, stress, or seasonal illness

Whether you're focused on immune health, recovery, or long-term wellness, Thymosin Alpha-1 is a trusted peptide for immune system support.

White Papers

Thymosin β4 and β10 Expression in Human Organs during Development: A Review.
Faa G, Messana I, Coni P, Piras M, Pichiri G, Piludu M, Iavarone F, Desiderio C, Vento G, Tirone C, Manconi B, Olianas A, Contini C, Cabras T, Castagnola M.
Cells. 2024 Jun 27;13(13):1115. doi: 10.3390/cells13131115.
PMID: 38994967 Free PMC article. Review.

Thymosin beta-4 denotes new directions towards developing prosperous anti-aging regenerative therapies.
Bock-Marquette I, Maar K, Maar S, Lippai B, Faskerti G, Gallyas F Jr, Olson EN, Srivastava D.
Int Immunopharmacol. 2023 Mar;116:109741. doi: 10.1016/j.intimp.2023.109741. Epub 2023 Jan 27.
PMID: 36709593 Review.

Thymosin beta 4 regulation of actin in sepsis.
Belsky JB, Rivers EP, Filbin MR, Lee PJ, Morris DC.
Expert Opin Biol Ther. 2018 Jul;18(sup1):193-197. doi: 10.1080/14712598.2018.1448381. Epub 2018 Mar 6.
PMID: 29508629 Free PMC article. Review.

Thymosin beta 4 and the eye: the journey from bench to bedside.
Sosne G.
Expert Opin Biol Ther. 2018 Jul;18(sup1):99-104. doi: 10.1080/14712598.2018.1486818.
PMID: 30063853 Review.

Thymosin beta 4 interactions.
Bubb MR.
Vitam Horm. 2003;66:297-316. doi: 10.1016/s0083-6729(03)01008-2.
PMID: 12852258 Review.

Cardioprotection by Thymosin Beta 4.
Pipes GT, Yang J.
Vitam Horm. 2016;102:209-26. doi: 10.1016/bs.vh.2016.04.004. Epub 2016 May 31.
PMID: 27450736 Review.

Thymosin beta 4.
Low TL, Goldstein AL.
Methods Enzymol. 1985;116:248-55. doi: 10.1016/s0076-6879(85)16018-0.
PMID: 4088087 No abstract available.

Thymosin beta 4 attenuates PrP(106-126)-induced human brain endothelial cells dysfunction.
Song K, Han HJ, Kim S, Kwon J.
Eur J Pharmacol. 2020 Feb 15;869:172891. doi: 10.1016/j.ejphar.2019.172891. Epub 2019 Dec 23.
PMID: 31877278

Thymosin Beta 4 Is a Potential Regulator of Hepatic Stellate Cells.
Kim J, Jung Y.
Vitam Horm. 2016;102:121-49. doi: 10.1016/bs.vh.2016.04.011. Epub 2016 May 31.
PMID: 27450733 Review.

Thymosin beta 4-Induced Autophagy Increases Cholinergic Signaling in PrP (106-126)-Treated HT22 Cells.
Han HJ, Kim S, Kwon J.
Neurotox Res. 2019 Jul;36(1):58-65. doi: 10.1007/s12640-018-9985-0. Epub 2018 Dec 15.
PMID: 30552633

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